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KMID : 0616120090400040394
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 4 p.394 ~ p.399
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Screening of Chinese Herbal Medicines with Inhibitory Effect on Aldose Reductase (3)
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Lee Yun-Mi
Kim Jong-Min
Kim Young-Sook
Jang Dae-Sik
Kim Joo-Hwan
Bae Ki-Hwan
Kim Jin-Sook
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Abstract
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Aldose reductase (AR) is a critical enzyme in the development of the diabetic complications. AR, the first enzyme
in the polyol pathway, catalyzes the reduction of the aldehyde form of glucose to sorbitol with concomitant conversion of
NADPH to NADP + . None of aldose reductase inhibitor (ARI) has achieved worldwide use because of limited efficacy or undesirable side effects. Therefore, evaluating natural sources for ARI potential may lead to the development of safer and more effective agents against diabetic complications. Forty eight Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, seven herbal medicines, Buddleja officinalis (whole plant), Lonicera japonica (leaf and flower), Polygonum aviculare (aerial part), Polygonum aviculare (whole plant), Salvia miltiorrhiza (root), Schisandra chinensis (stem), and Zanthoxylum armatum (leaf and stem) exhibited a significant inhibitory activity against AR. Particularly, L. japonica and P. aviculare showed two times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG).
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KEYWORD
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Diabetic complications, Aldose reductase inhibitor, Chinese herbal medicines
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